The Cheshire and Merseyside Local Drug Information System (LDIS) is a multi-disciplinary system which uses existing local resources to receive, evaluate, and disseminate alerts about new and/or novel, potent, adulterated, or contaminated drugs, regardless of their legal status. It uses elements from established local systems and is separate but complementary to the protocol used by Office for Health Improvement and Disparities (OHID) centres and national teams to assess drugs intelligence and, where required, issue national briefings or alerts. For further information please contact: LDIS@ljmu.ac.uk